Acyclovir resistance

TK-negative mutants may cause severe disease in infants and immunocompromised adults. The possibility of viral resistance to acyclovir should be considered in patients. Because foscarnet administration can lead to toxicity, it should be used only for patients whose disease justifies this risk and for whom acyclovir resistance can be. These patients may develop acyclovir-resistant VZV infection, with resistance related to selection of thymidine kinase-deficient or thymidine kinase-altered viral. Intravenous or oral administration of acyclovir reduces the incidence of symptomatic HSV infection. Unlike the results of therapy in older patients with herpes simplex.

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