Summary Do medications used to treat depression help smokers who are trying to quit. Multiple trials of bupropion (Zyban) for smoking cessation show that it increases the. Reviews and ratings for bupropion when used in the treatment of smoking cessation. 23 reviews submitted with a 7.8 average score. Nortriptyline is a tricyclic antidepressant that has been shown to be as effective as bupropion and NRT in aiding smoking cessation. 4 However, adverse effects associated.
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