A detailed overview of different benzodizepines, showing the potency and half-life people on potent benzodiazepines such as alprazolam, lorazepam (Ativan) or clonazepam. This finding sugg ests that alprazolam is not more dif-ficultto discontinue than clonazepam simply because of its half-life. Kales and colleagues (9,10) studied the effects. Best Answer: Clonazepam has an elimination half-life of about 20 to 80 hours. After the last dose, it takes about Five and a Half 'half-lives' before the drug is. Cytochrome P-450 including CYP3A, may play an important role in 39 clonazepam reduction and oxidation. The elimination half-life of clonazepam is typically 40 30 to 40 hours.
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