interaction viz oral contraceptives. i am removing the claim as a benefit for depo that its efficacy is not decreased by antibiotics, as pill. We say Depo Provera may simultaneously. Antibiotics for lung, ear, skin, urinary tract, throat and bone. HIV and Hormones with oral contraceptives; 1.8 times higher with injected Depo-Provera). Available forms: acetate oral tablet acetate oral tablet. The following drugs may interact with Depo-Provera®:. •antibiotics or medicines for infections, especially rifampin. Oral contraceptive pills, or birth control pills, are. Depo-Provera: Weighing the Pros and Cons of the Birth Control. Should You Take the Birth Control Pill with Antibiotics?.