Best Answer: They are different types of opioid analgesic (pain killer). Codeine is a natural opiate and is very similar to morphine, Oxycodone is a semi-synthetic. Everything you need to know about what’s the difference between oxycodone and tylenol codeine?. Information about common uses, side effects, interactions, dosages and. Is the narcotic in oxycodone the same as codeine? Whats the difference between the two? some help quick i am in alot of pain. So is codeine and oxycodone. Best Answer: Hydrocodone is NOT codeine. Codeine, hydrocodone and oxycodone are all different pain medications in the same family; they are all opioids. Oxycodone is.