DIGOXIN DOSAGE IN PREMATURE INFANTS O. Robert Levine M.D. 1, Sidney Blumenthal M.D. 1. 1 Babies Hospital, and Department of Pediatrics, College of Physicians and. In infants, sinus bradycardia may be a sign of digoxin toxicity. Any arrhythmia seen in a TEEN on digoxin should be considered as digoxin toxicity. Tell your doctor if you are pregnant before using this medication. Digoxin passes into breast milk. While there have been no reports of harm to nursing infants, consult. Digoxin has a large volume of distribution: 6-10 L/kg in adults, 10 L/kg in neonates, and as much as 16 L/kg in infants and toddlers. At therapeutic levels, the.