A list of the most common Zoloft side effects.. Zoloft Side Effects Zoloft (Sertraline) By Nancy Schimelpfening, About.com Guide Side effects of Zoloft may include nausea, drowsiness, sweating, dizziness, dry mouth, diarrhea, decreased appetite, sexual dysfunction and insomnia. Migraine - Reoccurring severe head pain usually with nausea, vomiting, dizziness, flashes or spots before the eyes, and ringing in the ears. Zoloft side effects The most common side effects associated with Zoloft include: dry mouth dizziness nausea diarrhea decreased sex drive ejaculatory and orgasmic delay or impairment.